GH + T3/T4 – The Fat Loss Power Combo Explained

Growth hormone (GH) is famous for its fat-burning and physique-enhancing properties.Thyroid hormones, T3 (liothyronine) and T4 (levothyroxine), control how fast your metabolism runs. Combine them, and you get one of the most potent fat loss Pharmaqolabsstore Semaglutide stacks used in bodybuilding and contest prep.But this isn’t a “more is better” situation. GH + thyroids can shred fat fast, but if you don’t run them correctly, you can burn muscle, crush your metabolism long-term, or wreck your blood sugar.

Why they work so well together

● GH increases fat mobilization (lipolysis) and shifts fuel use toward fat over carbs, but it also slows down the conversion of T4 into active T3 over time.

● T3/T4 directly increase metabolic rate, calorie burn, and energy turnover, and they counteract GH’s tendency to reduce T3 levels during extended use.

In simple terms: GH frees up fat for fuel, thyroid hormones make sure your body actually burns it.

The roles of each

Growth Hormone

● Stimulates hormone-sensitive lipase, releasing stored fat.
● Improves recovery and maintains muscle in a deficit.
● Raises IGF-1, which helps spare lean tissue.
● Best at steady, low-to-moderate dosing for long-term recomposition.

T3 (Liothyronine)

● Active thyroid hormone.
● Directly increases cellular energy turnover (ATP use).
● Powerful, but can burn muscle if calories and protein aren’t high enough.

T4 (Levothyroxine)

● Inactive thyroid hormone, converted to T3 in the body.
● Gentler than T3, safer for muscle retention if diet is dialed in.
● Works well for long-term use alongside GH without the “wired” feel of T3.

How GH affects thyroid function

Long-term GH use tends to:

● Lower circulating T3 slightly.
● Raise reverse T3 (rT3), which blocks T3 activity.
● This mild hypothyroid shift slows fat loss over time. Adding a small amount of T4 or T3 keeps thyroid output optimal and maximizes GH’s fat-burning potential.

Common GH + Thyroid protocols

1. GH + T4 (safe and long-term friendly)
● GH: 2–4 IU/day (split AM/PM or AM only)
● T4: 50–100 mcg/day (taken in the morning, empty stomach)
● Best for: Off-season recomposition or long preps.

 2. GH + Low T3 (more aggressive fat loss)
● GH: 3–5 IU/day
● T3: 12.5–25 mcg/day (split AM + early PM)
● Best for: Shorter cutting phases where you want faster results.

 3. GH + T3/T4 blend (contest prep level)
● GH: 4–6 IU/day
● T4: 50 mcg/day
● T3: 12.5–25 mcg/day
● Best for: Stage conditioning when you have muscle mass to spare and want maximum fat loss.

Things to watch out for

● Muscle loss – High-dose T3 without enough calories, protein, or anabolics will strip size fast.
● Insulin sensitivity – GH + high thyroid doses can push blood sugar up, monitor fasting glucose.
● Heart strain – Thyroid hormones increase heart rate and workload; don’t push them for months without breaks.
● Post-cycle metabolism crash – Dropping T3 cold turkey after long use can leave you sluggish. Taper down.

Real-world tips

1. T4 is safer for long runs – It’s less catabolic and works synergistically with GH for months without hammering muscle.
2. T3 is best as a short-term accelerator – Perfect in the last 4–6 weeks of a cut or prep.
3. Protein intake matters more here – GH + thyroid ramps up protein turnover, if intake is low, your body will break down muscle.
4. Monitor body temperature – Low temps = low thyroid activity; rising temps = higher metabolic output.
5. Pair with cardio – This stack makes cardio burn fat more efficiently, don’t waste it.

FAQ

1. Can I run GH without thyroid hormones?
Yes, but fat loss may slow over time as T3 naturally drops during GH use.

2. Is T4 alone enough with GH?

For most long-term users, yes, especially if muscle preservation is the goal.

3. Does T3 build muscle?

No—it’s purely metabolic. Too much will burn muscle unless you’re running anabolic support.

4. Should I run T3/T4 year-round?

No, give your thyroid a break. GH year-round is fine for some, but rotate thyroid phases.

5. How fast will fat loss be with this combo?

If diet and training are on point, expect fat loss to double compared to GH alone.

6. Do I need a PCT for T3/T4?

No, but you should taper down after use to let your thyroid normalize without rebound hypo symptoms.

Bottom line:

GH frees up stored fat Pharmaqolabsstore. Thyroid hormones make sure it gets burned. Together, they’re one of the most effective fat loss stacks in bodybuilding, but the dose, timing, and length of use decide whether you keep muscle or lose it. T4 is your long-haul partner, T3 is your short-term accelerator. Respect both, and they’ll carve you up fast.