Semaglutide vs Tirzepatide vs Retatrutide Which One’s Right for Your Cut?

Semaglutide vs Tirzepatide vs Retatrutide Which One’s Right for Your Cut?

You’ve seen them pop up in every fat loss thread, influencer story, and TRT clinic pitch
• Semaglutide
• Tirzepatide
• Retatrutide
These aren’t stimulants. They’re not clen, not ephedrine, not caffeine overdoses.
They’re peptides originally made for diabetics now being used by lifters, coaches, and even top-level preppers to drop body fat fast with almost zero effort.
They kill hunger, improve blood sugar, and for some people, make dieting stupidly easy. But they’re not the same compound, and not everyone should be jumping on the latest vial just because TikTok said it works.
Here’s how they work, what makes them different, and who should actually be using each one and who should stay the hell away.

Semaglutide

Semaglutide is a GLP-1 receptor agonist. It mimics a hormone your gut releases after eating, which slows down digestion and signals your brain that you’re full. Really full.

In the real world, that means your cravings vanish, portion sizes drop, and food feels like a chore. And that’s exactly why bodybuilders started using it during cuts, post-cycle phases, and aggressive fat loss setups.

In weekly injections, it can help strip body fat with no stimulants, no cardio, and no meal plans. It just makes you not care about food. Simple as that.

The downsides? Nausea is common, especially in the first couple of weeks. And it slows digestion so much that if you eat too fast or too heavy, you might regret it during your leg press set. You also have to be careful not to drop calories too low and lose muscle with it, especially if you’re enhanced and suppressing hunger already.

Best use case is for people with high appetite or high body fat, especially off-cycle or after long bulk phases. It works. But it can flatten you out and ruin training if you’re already lean.

Tirzepatide

Tirzepatide is the upgraded version. It hits GLP-1 like semaglutide, but also activates GIP, another hormone that controls insulin, appetite, and fat storage.

In plain English: it hits harder, with fewer side effects for most people. Hunger suppression is deeper, digestion feels smoother, and glucose control improves faster.

On the physique side, Tirzepatide seems to preserve more lean tissue during weight loss, and some users report better pump retention even in a deficit. That makes it popular in PCTs, mini-cuts, and even long-term recomp plans where fat loss needs to happen without blowing up your hormone recovery or muscle mass.

Like Semaglutide, it’s weekly dosing. But it tends to feel a little cleaner, less nausea, more stable blood sugar, and better energy.

Best for people already familiar with peptides, those with metabolic resistance, or enhanced athletes who are bridging or cruising and want to lean out without tanking test or cortisol.

Retatrutide

Retatrutide is the newest kid on the block, but it’s already available on our website. It hits GLP-1, GIP, and now glucagon receptors too, that third piece makes it different.

While Semaglutide and Tirzepatide mainly suppress appetite and control insulin, Retatrutide actually ramps up energy expenditure through glucagon signaling. So you’re not just eating less, you’re burning more.

People using Retatrutide report rapid fat loss with almost no desire to eat. And unlike its cousins, it seems to push thermogenesis. That means it doesn’t just slow you down and starve you, it actively speeds up the process.

For lifters, that’s huge. Especially during aggressive cuts, deep preps, or after long cycles where metabolism is cooked.

That said, it’s strong. Strong enough that if you’re already lean or training hard in a deficit, it might push you too far. Appetite can disappear to the point that even protein becomes hard to eat, and if you don’t manage training volume and recovery, your physique can go from shredded to flat overnight.